Helping you fulfil the global regulatory requirements for assessment of potential endocrine disrupting (ED) substances.

An emerging area of concern, with impact on human and environmental health, is endocrine disruption; the potential for chemical substances and mixtures to affect the endocrine systems of mammalian, vertebrate and invertebrate species.

The effects of endocrine-disrupting compounds – which interfere with the actions of naturally occurring hormones in humans and animals – have become a central point of focus for the scientific community and an area of concern for the wider public.

Authorities around the world have begun to regulate these substances and implement screening programs to minimize their environmental impact, requiring manufacturers in all industries to start testing their products for potential endocrine-disrupting effects.

There are now a variety of legislative implementations including:

  • United States’ Endocrine Disruptor Screening Program (EDSP)
  • European law regarding Plant Protection Products (1107/2009), REACH (1907/2006), Biocides (528/2012) and Human Pharmaceuticals
  • Article 8(3) of Directive 2001/83/EC and associated ERA Guidance EMEA/CHMP/SWP/4447/00 (Rev. 1.)
  • CLP Regulation (EC) No. 1272/2008

These pieces of legislation are supported by guidance documents from non-regulatory bodies such as the Organization for Economic and Cooperation and Development (OECD) and World Health Organization (WHO).

In response to these developments, our experts have been at the forefront of developing specific tests to identify endocrine disruptors and determine their effects, enabling us to address the concerns of the chemical industry, government and non-government organisations and the wider public.

OECD 229 FSTRA

Fish Short Term Reproduction Assay

  • with Zebrafish (Danio rerio)
  • with Japanese medaka (Oryzias latipes)
  • with Fathead minnow (Pimephales promelas)
OECD 230 21-day Fish Assay

A Short-Term Screening for Oestrogenic and

Androgenic Activity, and Aromatase Inhibition

  • with Zebrafish (Danio rerio)
  • with Japanese medaka (Oryzias latipes)
  • with Fathead minnow (Pimephales promelas)
OECD 231 AMA

Amphibian Metamorphosis Assay

  • with African clawed frog (Xenopus laevis)
OECD 234 FSDT

Fish Sexual Development Test

  • with Zebrafish (Danio rerio)
  • with Japanese medaka (Oryzias latipes)
OECD 240 MEOGRT

Extended One Generation Reproduction Test

  • with Japanese medaka (Oryzias latipes)
OECD 241 LAGDA

Larval Amphibian Growth and Development Assay

  • with African clawed frog (Xenopus laevis)
OCSPP 850.1500/OECD guideline in validation FFLC/ZEOGRT

Fish Full Life Cycle Test / Extended One Generation Reproduction Test

  • with Zebrafish (Danio rerio)
  • with Fathead minnow (Pimephales promelas)
OECD 248 XETA Xenopus Eleutheroembryonic Thyroid Assay

We are poised to support your Endocrine Disruptor testing and confirm and characterize the endocrine effects of your product.